The movie Chakram is about a foreign return, who has a dream of building a hospital at Pulivendula. He is in love with his colleague, Lakshmi who studied with him abroad. However he leaves her half way through after he realizes that he was struck with cancer. He does not want to hurt her and therefore he moves to Hyderabad and stays in place called Sahara Colony. There he tries to help people in the locality. Seeing all this, another girl who is also named Lakshmi falls in love with Chakram. The rest is a heart rending saga of the cancer-struck patients love station.